In 1730, the City of New Brunswick was so named in honor of the English royal house of Brunswick and became a colonial center for trade and commerce. Rutgers University, founded here in 1766, was the eighth college to be founded in the colonies and the only state university to have existed before the Revolutionary War. New Brunswick figures prominently in the American Revolution and early United States. During the Industrial Revolution, the city was vital to America's industry and commerce, utilizing the Raritan River, the Delaware & Raritan Canal, and rail lines. The city's preeminence as a pharmaceutical town dates to 1886 when the Johnson brothers launched their innovative startup in an old factory mill in New Brunswick. Johnson and Johnson is now the world's largest health care products manufacturer and retains its world headquarters at City Center.